Research Interests

The focus of my laboratory is the basic mechanisms that regulate Side Population stem cells. Stem cells reside in most of tissues in a quiescent state, but rapidly become activated to both repair and regenerate the adjacent tissues. We are studying several genes involved in different aspects of stem cell activation, including some that encode for ABC transporters, and others that regulate self-renewal and differentiation.

We are also interested in multidrug resistance and we use functional flow cytometry to examine the changes that occur in the accumulation of drugs into the cells over time. Additionally, we are using xenograft models to examine the genes that regulate bone marrow infiltration in cancer.



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